Scarlets and Wales full-back Morgan Stoddart has been forced to retire after failing to make a full recovery from the double leg fracture he suffered in the pre-World Cup Test against England in 2011.
The 28-year-old missed the whole of last season after suffering the horrific injury at Twickenham, but returned to action for his region in October.
However, Stoddart was still troubled by severe pain in his leg, and as a result has reluctantly chosen to hang up his boots.
He said: "It is with real sadness that I have to announce my retirement from rugby and it has been a difficult few months as I come to terms with the fact that I was not going to return to full fitness.
"I have been very fortunate to play for the Scarlets and Wales and have enjoyed every game in my professional career working alongside some brilliant fellow professionals.
"I worked as hard as possible in the year I was off to get back on the pitch and that can be a difficult period for any injured player mentally, as well as physically, but I was determined to get back to playing.
"But ever since I've been back on the field I've had significant pain in the leg throughout and that has not improved. Following a series of medical tests and consultations, detailed scans and strength tests, I've been advised that I cannot continue."
Stoddart, who also featured as a winger, won eight caps in total for Wales, making his first appearance against South Africa in November 2007 and scoring the first of his five tries for his country in the same match.
He also made 85 appearances for the Scarlets, scoring 26 tries.
Stoddart added: "I'll have to adapt and it's important to give yourself time to consider things in the future after such an intense life playing rugby, but I have already started thinking ahead and there are many exciting opportunities for me related to my career to look at and take forward which will keep me occupied now."