Medical crews are currently assessing those involved in a two-vehicle crash at the Ashton Road and Swan Lane junction of the B4696.
The crash, which happend within the hour, has led to Royal Wootton Bassett and Cricklade Police closing the road.
Drivers are urged to find an alternative route while emergency services remain at the scene.
The vehicles will also need to be removed from the scene before the road can reopen.
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