Palestinian health officials say dozens of people have been killed in an Israeli airstrike in central Gaza.

It is one of the deadliest strikes since Israel declared war against Gaza’s Hamas rulers following a deadly cross-border attack by the Islamic militant group.

The strike took place on Sunday night in the Maghazi refugee camp, east of Deir al-Balah.

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Israeli army troops are seen near the Gaza Strip border (AP Photo/Ariel Schalit)

Gaza Health Ministry spokesman Ashraf al-Qidra said at least 68 people were killed.

The Israeli military had no immediate comment.

The strike comes on a weekend that has seen more than a dozen Israeli soldiers killed in combat in the Gaza Strip in some of the bloodiest days of battle since the start of Israel’s ground offensive in late October – and a sign that Hamas is still putting up a fight despite weeks of brutal war.

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Smoke rises following an Israeli bombardment in the Gaza Strip (AP Photo/Ariel Schalit)

The mounting death toll among Israeli troops, confirmed by authorities, is likely to play an important factor in Israeli public support for the war, which was sparked when Hamas-led militants stormed communities in southern Israel on October 7, killing 1,200 and taking 240 hostages.

The war has devastated parts of the Gaza Strip, killed more than 20,000 Palestinians and displaced nearly 85% of Gaza’s 2.3 million people.

Israelis still stand firmly behind the country’s stated goals of crushing Hamas’ governing and military capabilities and releasing the remaining 129 captives.

That support has remained steady despite rising international pressure against Israel’s offensive and the soaring death toll and unprecedented suffering among Palestinians.

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A Palestinian woman stands in her home after an Israeli strike in Rafah (AP)

But the growing number of dead soldiers could undermine that support. Soldiers’ deaths are a sensitive and emotional topic in Israel, a country with compulsory military service for most Jews.

The names of fallen soldiers are announced at the top of hourly newscasts, and in a small country of about nine million people, virtually every family knows a relative, friend or co-worker who has lost a family member in war.

The 14 Israeli soldiers killed on Friday and Saturday died in battles in central and southern Gaza, an indication of how Hamas is still putting up tough resistance against advancing Israeli troops, even as Israel claims to have dealt a serious blow to the militant group.

According to Israeli Army Radio, four soldiers were killed when their vehicle was struck by an anti-tank missile. The others were killed in separate, sporadic fighting.

Another soldier was killed in northern Israel by fire from the Lebanese Shia militant group Hezbollah, which has kept up low-level fighting with Israel since the war with Hamas erupted, raising fears of a wider regional conflict.

Their deaths bring the number of Israeli soldiers killed since the ground offensive began to 153.

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Tens of thousands of Palestinians have been killed (AP)

Even if Israelis have been supportive of the war effort, there has been widespread anger against the government of Prime Minister Benjamin Netanyahu, which many criticise for failing to protect civilians on October 7 and promoting policies that allowed Hamas to gain strength over the years.

On Saturday night, thousands of people demonstrated in pouring rain in Tel Aviv, chanting “Bibi, Bibi, we don’t want you any more”, referring to Mr Netanyahu by his nickname.

The Israeli Prime Minister has avoided claiming responsibility for the military and policy failures leading up to October 7, saying he would answer tough questions once the fighting is over.

On Saturday, Israeli military spokesman Rear Admiral Daniel Hagari said forces were expanding their offensive in northern and southern Gaza and troops were fighting in “complex areas” in Khan Younis, Gaza’s second-largest city, where Israel believes Hamas leaders are hiding.

Israeli Prime Minister Benjamin Netanyahu told a Cabinet meeting: “The war exacts a very heavy price from us but we have no choice but to continue fighting.”

There has been widespread anger against Mr Netanyahu’s government, which many criticise for failing to protect civilians on October 7 and promoting policies that allowed Hamas to gain strength over the years.

Mr Netanyahu has avoided accepting responsibility for the military and policy failures.

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An Israeli Apache helicopter fires flares over the Gaza Strip (AP Photo/Ariel Schalit)

Meanwhile, efforts towards another ceasefire continued.

On Sunday, the head of the Palestinian Islamic Jihad group also involved in the October 7 attack, Ziyad al-Nakhalah, arrived in Cairo for talks.

The militant group said it was prepared to consider releasing hostages only after a ceasefire.

Hamas’ top leader Ismail Haniyeh travelled to Cairo for talks days earlier.

Egypt and Qatar have been key mediators in the conflict.

Israel’s offensive has been one of the most devastating military campaigns in recent history and has claimed a staggering toll on Palestinian civilians. More than two-thirds of the 20,000 killed were women and children, according to the health ministry in Hamas-controlled Gaza, which does not differentiate between civilians and combatants.

The Palestinian Red Crescent said Sunday morning that a 13-year-old boy was shot and killed by an Israeli drone attack while inside the building of al-Amal hospital, which is run by the charity, in Khan Younis.

Palestinians reported heavy Israeli bombardment and gunfire Sunday morning in the town of Jabaliya, an area north of Gaza City that Israel had previously claimed to control. Sounds of explosions and gunfire echoed across the town with Israeli warplanes flying over the area, they said.

Israel blames Hamas for the high civilian death toll, citing the militants’ use of crowded residential areas and tunnels. Israel has launched thousands of airstrikes since October 7, and has largely refrained from commenting on specific attacks.

The mounting casualties on both sides came days after the United Nations Security Council passed a watered-down resolution calling for the speedy delivery of humanitarian aid for hungry and desperate Palestinians and the release of all the hostages, but not for a ceasefire.

Following the UN resolution, it was not immediately clear how and when aid deliveries would accelerate. Trucks enter through two crossings — Rafah on the border with Egypt and Kerem Shalom on the border with Israel. On Friday, fewer than 100 trucks entered, the UN said — far below the daily average of 500 before the war.

Both crossings were closed on Saturday by mutual agreement among Israel, Egypt and the UN, Israeli officials said.